- Through Switzerland :

Strasbourg - Bâle then Bâle - Genève then Genève - Annecy then Annecy - Chambéry then Chambéry - Grenoble

    - Through France :

Strasbourg - Mulhouse then Mulhouse - Besançon then Besançon - Bourg then Bourg - Lyon then Lyon - Grenoble

Then follow directions from Grenoble